Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways
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چکیده
منابع مشابه
Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways
T HE traditional view of growth factor receptors and hormone receptors in general is that a specific ligand directly recognizes a highly selective binding site on its cognate receptor and, thereby, activates receptor-dependent signaling and biological responses. In the case of the EGF receptor, several structurally related proteins (EGF, transforming growth factor alpha, amphiregulin, betacellu...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1999
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.146.4.697